New Antiarrhythmic Drugs: Tocainide, Mexiletine, Flecainide, Encainide, and Amiodarone
نویسندگان
چکیده
منابع مشابه
A prospective comparison of class IA, B, and C antiarrhythmic agents in combination with amiodarone in patients with inducible, sustained ventricular tachycardia.
BACKGROUND Clinical experience suggests that combinations of antiarrhythmic agents provide more effective control of ventricular tachyarrhythmias than does therapy with single agents. METHODS AND RESULTS Antiarrhythmic and electrophysiological effects of three class I antiarrhythmic agents, one from each subclass A, B, and C, were assessed in single use and in combination with amiodarone in p...
متن کاملAcute effects of combination of IB and IC antiarrhythmics for the treatment of ventricular tachycardia.
There are limited data on the effects of Class IB and IC antiarrhythmic drug combination for the treatment of ventricular tachycardia. The present study evaluated this combination in 12 patients who had sustained ventricular tachycardia (SuVT) during programmed electrical stimulation (PES) and failed IC antiarrhythmic therapy. Following combination of lidocaine and a IC agent (7 with encainide ...
متن کاملQuinidine-related mortality in the short-to-medium-term treatment of ventricular arrhythmias. A meta-analysis.
BACKGROUND The interim results of the Cardiac Arrhythmia Suppression Trial requires physicians to use a higher threshold for employing antiarrhythmic agents in the treatment of benign or potentially lethal ventricular arrhythmias. Many have managed patients by switching to the traditional class I quinidine despite its known proarrhythmic tendency. METHODS AND RESULTS To evaluate the relation ...
متن کاملAntiarrhythmic drugs.
Most patients with cardiac arrhythmias require treatment with antiarrhythmic drugs, although recent advances in surgical and electrical techniques are promising. The ideal antiarrhythmic compound should have: (1) A wide range of therapeutic activity in both atrial and ventricular arrhythmias. (2) Parenteral and oral formulations to permit simple dosage schedules. (3) Pharmacokinetic properties ...
متن کاملAntiarrhythmic Drugs
Cardiac arrhythmias result from alterations in the orderly sequence of depolarization followed by repolarization in the heart. Cardiac arrhythmias may result in alterations in heart rate or rhythm and arise from alterations in impulse generation or conduction. The clinical implications of disordered cardiac activation range from asymptomatic palpitations to lethal arrhythmia. Pharmacological ma...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 1987
ISSN: 0025-6196
DOI: 10.1016/s0025-6196(12)65077-0